Clinical Trial Design – A Review – With Emphasis on Acute Intervertebral Disc Herniation

Jeffery ND, Olby NJ, Moore SA and the Canine Spinal Cord Injury Consortium (CANSORT-SCI) (2020) Clinical Trial Design – A Review – With Emphasis on Acute Intervertebral Disc Herniation. Front. Vet. Sci. 7:583. doi: 10.3389/fvets.2020.00583

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There is a clear need for new methods of treatment of acute disc herniation in dogs, most obviously to address the permanent loss of function that can arise because of the associated spinal cord injury. Clinical trials form the optimal method to introduce new therapies into everyday clinical practice because they are a reliable source of unbiased evidence of effectiveness. Although many designs are available, parallel cohort trials are most widely applicable to acute disc herniation in dogs…

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